Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html


Study Counts

Type Study_count
Total_Studies 1352
interventional 1197
Observational 145
Registry 10

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type Study_Count
Drug 371
Drug|placebo 335
Behavioral 159
Device 129
Other 52
Behavioral|Drug 21
Behavioral|Other 14
Dietary Supplement 10
Drug|Other 9
Dietary Supplement|placebo 8
Drug|Procedure 8
Procedure 8
Behavioral|Device 7
Device|Drug|placebo 6
Device|Drug 4
Device|Other 4
Drug|Other|placebo 4
Behavioral|Drug|Other 3
Biological 3
Dietary Supplement|Drug 3
Genetic|Other 3
Behavioral|Device|Drug 2
Behavioral|Drug|placebo 2
Behavioral|Drug|Procedure 2
Biological|placebo 2
Device|Procedure 2
Diagnostic Test|Other 2
Drug|Genetic 2
Drug|placebo|Procedure 2
Genetic 2
Behavioral|Device|Drug|Radiation 1
Behavioral|Device|Other 1
Behavioral|Diagnostic Test|Other 1
Behavioral|Other|Radiation 1
Biological|Drug 1
Combination Product 1
Combination Product|Drug|Other 1
Combination Product|Other 1
Combination Product|placebo 1
Device|Drug|Other|placebo 1
Device|placebo 1
Diagnostic Test 1
Diagnostic Test|Drug|placebo 1
Dietary Supplement|Drug|Other 1
Other|placebo 1
Other|Procedure 1
placebo 1
Radiation 1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country Study_Count
United States 573
Canada 86
NA 83
China 37
Germany 35
Japan 26
France 18
Taiwan 18
United Kingdom 18
Israel 16
United States|Canada 16
Korea, Republic of 14
Denmark 11
United States|Puerto Rico 11
Brazil 10
Australia 9
Spain 8
Sweden 8
Switzerland 8
Belgium 7
Hong Kong 6
Netherlands 6
Norway 6
Egypt 4
Austria 3
India 3
Germany|Netherlands 2
Iran, Islamic Republic of 2
Japan|Korea, Republic of 2
Pakistan 2
Poland 2
Portugal 2
United States|Australia 2
United States|Bulgaria|Canada|Colombia|Estonia|France|Germany|Hungary|Israel|Italy|Korea, Republic of|Latvia|Mexico|Poland|Russian Federation|Serbia|South Africa|Spain|Ukraine|United Kingdom 2
United States|China 2
United States|India 2
United States|Israel 2
United States|Mexico 2
Argentina|Belgium|Chile|Costa Rica|Germany|Italy|Peru|Poland|Slovakia|Spain|Sweden 1
Argentina|Brazil|Bulgaria|Chile|Colombia|Croatia|France|Germany|Hungary|Poland|Romania|Russian Federation|Serbia|Slovakia|South Africa|Spain|Ukraine 1
Argentina|Bulgaria|Canada|Chile|Croatia|Mexico|Russian Federation 1
Argentina|Bulgaria|Croatia|Czech Republic|Finland|France|Mexico|Poland|Romania|Russian Federation|Serbia|Slovakia|South Africa 1
Argentina|Chile|Greece|Hong Kong|Morocco|Russian Federation|Singapore|South Africa|Spain|Taiwan|Tunisia 1
Australia|Belgium|Canada|Czech Republic|Finland|France|Germany|Norway|Poland|Romania|South Africa|Sweden 1
Australia|Belgium|Finland|Netherlands|Norway|Russian Federation 1
Australia|Canada 1
Australia|Canada|Mexico|Russian Federation|Taiwan 1
Australia|Czech Republic|France|Germany|Korea, Republic of|Latvia|Lithuania|Malaysia|Netherlands|Poland|Russian Federation|South Africa|Taiwan|Ukraine|United Kingdom 1
Australia|Japan|Korea, Republic of|Malaysia|Taiwan 1
Australia|Turkey 1
Austria|Croatia|France|Hungary|Poland|Romania|Russian Federation|Serbia|Ukraine|United Kingdom 1
Austria|Czech Republic|Germany 1
Austria|Czech Republic|Italy|Romania|Slovakia|Spain 1
Austria|Russian Federation 1
Bangladesh 1
Belgium|Czech Republic|Finland|France|Germany|Slovakia 1
Belgium|Estonia|Finland|France|Germany|Greece|India|Korea, Republic of|Malaysia|Morocco|Taiwan|Tunisia|Turkey 1
Belgium|Germany|Netherlands 1
Belgium|Germany|Poland 1
Bulgaria|Croatia|Czech Republic|Estonia|France|Montenegro|Netherlands|Serbia 1
Bulgaria|Croatia|Former Serbia and Montenegro|Romania 1
Bulgaria|Croatia|Romania|Serbia 1
Bulgaria|Czechia|Finland|Hungary|Russian Federation|Slovakia|Ukraine 1
Bulgaria|Estonia|France|Germany|Hungary|Italy|Latvia|Poland|Russian Federation|Serbia|South Africa|Spain|United Kingdom 1
Bulgaria|Estonia|Latvia 1
Bulgaria|Hungary|Moldova, Republic of|Romania|Russian Federation|Ukraine 1
Bulgaria|United States|Finland|Germany|Poland|Russian Federation|Ukraine 1
Chile 1
Chile|Mexico|Romania|Russian Federation|Slovakia|South Africa|Ukraine 1
China|Hong Kong 1
Croatia 1
Croatia|Estonia|Finland|France|Latvia|Lithuania|Poland|Romania|Slovakia|South Africa 1
Croatia|Finland|Germany|Hong Kong|India|Japan|Korea, Republic of|Latvia|Malaysia|Philippines|Poland|Romania|Russian Federation|Serbia|Taiwan|Ukraine 1
Czech Republic|Estonia|Finland|France|Germany|Hungary|Latvia|Lithuania|Poland|Sweden 1
Czechia 1
Denmark|France|Greece|Hungary|Italy|Netherlands|Romania|Slovenia|Spain|Sweden|Turkey 1
Estonia 1
Estonia|Finland 1
Estonia|Finland|Germany|Lithuania 1
Estonia|Finland|Germany|Serbia|Slovakia 1
Estonia|France|Italy|Korea, Republic of|Poland|Spain 1
Estonia|Russian Federation 1
Ethiopia 1
Finland 1
Finland|Germany|Serbia|Slovakia 1
Finland|Poland|Russian Federation|Serbia|Slovakia|South Africa|Ukraine|United Kingdom 1
Finland|United States|Bulgaria|France|Germany|Japan|Russian Federation|Ukraine 1
France|Ireland|Spain|United Kingdom 1
France|Israel|United Kingdom 1
France|Italy|Lithuania|Spain 1
France|Italy|Russian Federation|South Africa 1
Germany|Australia|Austria|Belgium|Bulgaria|Denmark|Hungary|Italy|Portugal|Romania|Slovakia|Spain|United Kingdom 1
Germany|Poland|Russian Federation|United States|Canada|France|Serbia 1
India|China|Korea, Republic of|Taiwan 1
Italy 1
Mexico 1
Mexico|Canada|China|Finland|Korea, Republic of|Malaysia|Philippines|South Africa|Spain 1
Romania 1
Russian Federation 1
Russian Federation|Belgium|Canada|Chile|Estonia|Finland|France|Germany|Netherlands|Slovakia|South Africa|Sweden 1
Russian Federation|United States|Bulgaria|Canada|Colombia|Estonia|France|Germany|Hungary|Italy|Korea, Republic of|Latvia|Mexico|Poland|Serbia|South Africa|Spain|Ukraine|United Kingdom 1
Sweden|Australia|Austria|Belgium|Canada|Czech Republic|Finland|France|India|Korea, Republic of|Lithuania|Malaysia|Norway|Philippines|Russian Federation|Serbia|Ukraine 1
Turkey 1
Ukraine 1
Ukraine|United States|Austria|Canada|Germany|Russian Federation|Slovakia|South Africa 1
United States|Argentina|Australia|Chile|United Kingdom 1
United States|Argentina|Austria|Belgium|Brazil|Canada|Czechia|France|Lithuania|Poland|Spain|Turkey 1
United States|Argentina|Belgium|Croatia|France|Germany|Greece|Italy|Korea, Republic of|Mexico|Puerto Rico|Romania|Russian Federation|Slovakia|Spain|Turkey 1
United States|Argentina|Canada|Mexico 1
United States|Argentina|Chile|Colombia|Mexico|Peru 1
United States|Argentina|Estonia|Finland|Russian Federation|Ukraine 1
United States|Argentina|Finland|France|Mexico|Sweden 1
United States|Argentina|Finland|Poland|Russian Federation 1
United States|Australia|Austria|Belgium|Germany|Sweden|United Kingdom 1
United States|Australia|Bulgaria|Canada|Germany|Hungary|Poland|Puerto Rico 1
United States|Australia|Canada 1
United States|Australia|Croatia|France|Germany|Korea, Republic of|Latvia|Lithuania|Malaysia|Netherlands|Poland|Russian Federation|Serbia|South Africa|Taiwan|Ukraine|United Kingdom 1
United States|Australia|Netherlands|New Zealand|South Africa 1
United States|Australia|Puerto Rico 1
United States|Belgium|Brazil|Bulgaria|France|Hungary|Italy|Poland|Spain 1
United States|Belgium|Czechia|Estonia|Finland|Germany|Hungary|Poland|Romania|South Africa|Sweden 1
United States|Belgium|Germany|Netherlands|United Kingdom 1
United States|Brazil|Chile|Lithuania|Mexico|Netherlands|Spain 1
United States|Bulgaria 1
United States|Bulgaria|Canada|Estonia|Finland|Germany|Korea, Republic of|Latvia|Lithuania|Mexico|Poland|Romania|Russian Federation|Sweden|Ukraine|United Kingdom 1
United States|Bulgaria|Canada|Puerto Rico|Romania|Russian Federation|Slovakia|United Kingdom 1
United States|Bulgaria|Estonia|Germany|Hungary|Korea, Republic of|Malaysia|Slovakia|South Africa|Spain|Taiwan 1
United States|Bulgaria|Estonia|Germany|Hungary|Ukraine 1
United States|Bulgaria|Estonia|Germany|Russian Federation 1
United States|Bulgaria|Finland|Germany|Romania|Russian Federation|Serbia|Ukraine 1
United States|Bulgaria|Finland|Poland 1
United States|Canada|Chile|Colombia|Croatia|Estonia|Finland|France|Latvia|Lithuania|Poland|Romania|Slovakia|South Africa 1
United States|Canada|Croatia|Mexico|Puerto Rico|Spain 1
United States|Canada|France|Germany|Hungary|Poland|Romania|Russian Federation|Serbia|Slovakia|Ukraine 1
United States|Canada|France|Germany|Israel 1
United States|Canada|France|Poland|Slovakia 1
United States|Canada|Germany|Hungary|Romania|Russian Federation|Ukraine 1
United States|Canada|Germany|Israel 1
United States|Canada|Germany|Puerto Rico 1
United States|Canada|Israel 1
United States|Canada|Italy 1
United States|Canada|Mexico 1
United States|Canada|Poland|Russian Federation|United Kingdom 1
United States|Chile 1
United States|Chile|Estonia|Germany|Korea, Republic of|Mexico|Russian Federation|South Africa 1
United States|Chile|Estonia|Russian Federation 1
United States|Chile|Germany|Japan|Mexico|Poland|Romania|Russian Federation|Taiwan 1
United States|Chile|Mexico 1
United States|Chile|Slovakia|South Africa 1
United States|Croatia|Czech Republic|France|Mexico|Russian Federation|Sweden|Turkey 1
United States|Croatia|Czechia|Finland|Japan|Puerto Rico|Slovakia 1
United States|Czechia|Finland|Germany|Greece|Israel|Poland|Russian Federation|Spain 1
United States|Czechia|Finland|Poland|Puerto Rico|Serbia|Slovakia 1
United States|Estonia|Finland|Former Serbia and Montenegro|France|Germany|Latvia|Lithuania|Poland|Slovakia|South Africa 1
United States|Estonia|Finland|Germany|Poland 1
United States|Estonia|Finland|Slovakia|Sweden|Ukraine 1
United States|Finland|Poland|Russian Federation|Serbia|Slovakia|Ukraine|United Kingdom 1
United States|France|Germany|Italy|Russian Federation|Sweden 1
United States|France|Germany|Puerto Rico|Romania|Sweden 1
United States|France|Germany|Russian Federation|Slovakia|South Africa|Ukraine 1
United States|France|Mexico|Puerto Rico 1
United States|Germany|Hungary|Poland|Slovakia 1
United States|Germany|Moldova, Republic of|Russian Federation|Ukraine|United Kingdom 1
United States|India|Puerto Rico 1
United States|Japan 1
United States|Japan|Latvia|Poland|Russian Federation|South Africa|Ukraine 1
United States|Moldova, Republic of|Russian Federation|Spain|Ukraine|United Kingdom 1
United States|Moldova, Republic of|Russian Federation|Ukraine|United Kingdom 1
United States|Romania 1
United States|Russian Federation|Serbia|Ukraine|United Kingdom 1
United States|Taiwan 1

Sites per Study

Site_count Study_Count
1 754
2 70
3 12
4 19
5 13
6 14
7 10
8 11
9 14
10 4
11 4
12 7
13 9
14 9
15 9
16 6
17 4
18 4
19 6
20 6
21 6
22 6
23 7
24 7
25 8
26 4
27 4
28 2
29 2
31 4
32 7
33 4
34 6
35 7
36 2
37 5
38 5
39 2
40 2
41 3
42 2
43 7
44 8
45 4
46 2
47 5
48 2
49 3
50 3
51 4
52 1
53 3
54 2
56 5
57 2
58 2
59 2
60 2
61 4
62 2
63 3
65 1
66 2
67 1
68 1
69 1
70 3
71 2
72 2
73 2
74 3
75 1
76 2
77 1
78 2
79 2
82 1
85 2
87 1
89 1
90 1
92 3
93 1
94 1
98 1
99 1
101 2
106 1
107 1
117 1
124 1
128 1
136 1
137 1
144 1
158 1
168 1

Phase

Phase Study_Count
N/A 402
Phase 3 267
Phase 2 192
Phase 4 181
Phase 1 88
Phase 2/Phase 3 30
Phase 1/Phase 2 25
Early Phase 1 12

Number of Arms

Number_of_Arms Count_of_Studies
1 209
2 563
3 185
4 78
5 10
6 6
7 3
8 3
9 2
11 1
13 1
14 1
NA 135

Enrollment Metrics by Phase

Measure Early.Phase.1 N.A Phase.1 Phase.1.Phase.2 Phase.2 Phase.2.Phase.3 Phase.3 Phase.4
Min. 9.0000 6.000 4.00000 12.00 5.0000 10.0000 8.0000 2.0000
1st Qu. 17.5000 37.000 18.00000 25.00 36.2500 24.5000 200.0000 34.2500
Median 20.5000 70.000 30.00000 42.00 103.0000 60.0000 414.0000 77.5000
Mean 266.4167 196.875 44.97701 62.64 197.0158 145.8333 490.9432 266.7556
3rd Qu. 58.7500 133.250 56.00000 65.00 250.0000 120.0000 600.0000 268.2500
Max. 2700.0000 17300.000 260.00000 271.00 2530.0000 720.0000 6058.0000 8000.0000

Trial Group Type

group_type Group_Count
Experimental 1246
Active Comparator 467
Placebo Comparator 430
NA 135
No Intervention 93
Other 84
Sham Comparator 69

Intervention Model

intervention_model Study_Count
Parallel Assignment 814
Single Group Assignment 261
Crossover Assignment 79
Factorial Assignment 17
NA 17
Sequential Assignment 9

Primary Purpose

primary_purpose Study_Count
Treatment 1021
Basic Science 54
Other 31
Prevention 24
Health Services Research 19
Supportive Care 16
Diagnostic 14
NA 13
Screening 4
Educational/Counseling/Training 1

Observational Studies

Studies by Country

Country Study_Count
United States 79
NA 16
Canada 9
China 5
France 5
Spain 5
Denmark 4
Germany 4
United Kingdom 3
Greece 2
Switzerland 2
Austria|China|Hong Kong|Israel|Lebanon|Malaysia|Mexico|Philippines|Saudi Arabia|Singapore|Taiwan|Thailand|United Arab Emirates 1
Chile 1
Egypt 1
Hong Kong 1
Iran, Islamic Republic of 1
Israel 1
Italy 1
Korea, Republic of 1
Malaysia 1
Taiwan 1
United States|Canada|France|Italy 1

Sites per Study

Site_count Study_Count
1 111
2 13
3 3
5 5
8 1
10 2
20 1
22 1
25 1
27 1
29 1
44 1
48 1
55 1
57 1
106 1

Enrollment Metrics

Measure Observational
Min 1.000
1st Qu 55.500
Median 117.500
Mean 1279.937
3rd Qu 372.250
Max 48865.000

Observation Model

observational_model Study_Count
Cohort 44
NA 35
Case-Control 23
Case-Only 16
Case Control 16
Other 6
Ecologic or Community 3
Defined Population, Natural History 1
Family-Based 1

Time Perspective

time_perspective Study_Count
Prospective 66
Cross-Sectional 32
Retrospective 22
NA 20
Other 4
Cross-Sectional, Prospective 1

Registries

Studies by Country

Country Study_Count
NA 2
United States 2
Argentina 1
Canada 1
Denmark 1
Germany 1
Korea, Republic of 1
Poland 1

Sites per Study

Site_count Study_Count
1 9
8 1

Enrollment Metrics

Measure Registries
Min 40.00
1st Qu 71.25
Median 155.00
Mean 728.10
3rd Qu 275.00
Max 5716.00

Registry Model

observational_model Study_Count
Cohort 8
Case-Control 1
Other 1

Time Perspective

time_perspective Study_Count
Prospective 8
Cross-Sectional 1
Other 1

Follow-up

target_duration Study_Count
6 Months 2
1 Month 1
1 Week 1
1 Year 1
12 Months 1
12 Weeks 1
2 Weeks 1
3 Months 1
3 Years 1

Overview of Studies

Interventional Trials

#If less then 500 trials

Observational Studiess

#If less then 500 studies

nct_id brief_title link overall_status source primary_completion_date
NCT04455646 Combining H1-Coil Deep Transcranial Magnetic Stimulation (dTMS) and App-guided CBT in Subjects With Major Depression Disorder (MDD) https://ClinicalTrials.gov/show/NCT04455646 Recruiting Brainsway 2021-08-26
NCT04209296 Chart Review of Patients Undergoing Ketamine Infusions https://ClinicalTrials.gov/show/NCT04209296 Active, not recruiting Brain and Cognition Discovery Foundation 2020-12-03
NCT03254342 MRS and Medication Response: A Pilot Study https://ClinicalTrials.gov/show/NCT03254342 Recruiting Stanford University 2020-08-06
NCT03207503 Neurobehavioral Mechanisms of Emotion Regulation in Depression Across the Adult Lifespan https://ClinicalTrials.gov/show/NCT03207503 Recruiting Duke University 2022-08-31
NCT03084042 Emotional Brain Networks & Cognitive Functioning in Depression and Anxiety https://ClinicalTrials.gov/show/NCT03084042 Recruiting University of Electronic Science and Technology of China 2018-12-31
NCT03067506 Cognitive and Mood Assessment Data in Major Depressive Disorder Using Digital Wearable Technology https://ClinicalTrials.gov/show/NCT03067506 Completed Takeda 2017-07-03
NCT03040388 Exploring Effects of Electroconvulsive Therapy on the Human Brain in Depression - The Danish ECT/MRI Study https://ClinicalTrials.gov/show/NCT03040388 Recruiting University of Copenhagen 2020-04-30
NCT03031665 Sex, Hormones and Gamma-Aminobutyric Acid (GABA) in Stress Induced Anhedonia in Depression https://ClinicalTrials.gov/show/NCT03031665 Recruiting Mclean Hospital 2021-04-30
NCT03026036 Neuroimaging Studies of Reward Processing in Depression https://ClinicalTrials.gov/show/NCT03026036 Recruiting Mclean Hospital 2021-02-28
NCT03014544 Study to Evaluate the Performance Validity and Test-Retest Reliability of a Computer-Administered Cognitive Test Battery in Participants With Major Depressive Disorder (MDD) https://ClinicalTrials.gov/show/NCT03014544 Completed Janssen Research & Development, LLC 2019-04-08
NCT03001440 A 7-year Assessment on Subject Understanding of ZYBAN/ WELLBUTRIN Associated Risks https://ClinicalTrials.gov/show/NCT03001440 Completed GlaxoSmithKline 2016-12-28
NCT02998762 Long-Term Follow Up Study https://ClinicalTrials.gov/show/NCT02998762 Active, not recruiting University Health Network, Toronto 2021-11-30
NCT02983318 Molecular Imaging of Brain Inflammation in Depressive Disorders https://ClinicalTrials.gov/show/NCT02983318 Completed Lawson Health Research Institute 2019-03-20
NCT02855580 Integrating Pharmacogenomic Testing Into a Child Psychiatry Clinic https://ClinicalTrials.gov/show/NCT02855580 Completed University of Florida 2017-07-06
NCT02843373 Brain-Based Biomarkers in Response to TMS in MDD https://ClinicalTrials.gov/show/NCT02843373 Recruiting Stanford University 2022-07-31
NCT02752178 Peripheral Immunomarker Validation in Treatment-resistant Depression https://ClinicalTrials.gov/show/NCT02752178 Completed University of Cambridge 2018-09-30
NCT02746367 Bipolar Proteomic Assay Validation Study https://ClinicalTrials.gov/show/NCT02746367 Completed Myriad Genetic Laboratories, Inc. 2018-11-08
NCT02739932 Adolescent Mental Health: Canadian Psychiatric Risk and Outcome Study https://ClinicalTrials.gov/show/NCT02739932 Active, not recruiting University of Calgary 2021-08-31
NCT02737540 Neuropsychological Factors Associated With Vulnerability to Suicidal Behavior in Depressed Elderly Patients https://ClinicalTrials.gov/show/NCT02737540 Recruiting Centre Hospitalier Universitaire de Nīmes 2020-10-31
NCT02715778 Translational Investigation of Gestational Environment on Neurobehavioral Function in Children https://ClinicalTrials.gov/show/NCT02715778 Completed Massachusetts General Hospital 2017-09-30
NCT02681822 Multi-center Imaging Genetics Studies in China https://ClinicalTrials.gov/show/NCT02681822 Recruiting Tianjin Medical University General Hospital 2019-12-31
NCT02568865 Noninvasive Physiologic Sensors to Assess Depression https://ClinicalTrials.gov/show/NCT02568865 Completed Massachusetts General Hospital 2018-07-01
NCT02548949 Korean Post Marketing Surveillance to Observe Effectiveness and Safety of PRISTIQ https://ClinicalTrials.gov/show/NCT02548949 Completed Pfizer 2019-10-16
NCT02508493 Validation of the THINC-it Tool for Cognitive Dysfunction in Major Depressive Disorder https://ClinicalTrials.gov/show/NCT02508493 Completed Brain and Cognition Discovery Foundation 2016-07-31
NCT02489305 Study to Evaluate Potential Predictors of Relapse in Participants With Major Depressive Disorder (MDD) https://ClinicalTrials.gov/show/NCT02489305 Completed Janssen Research & Development, LLC 2018-05-01
NCT02474680 Evaluation of Pharmacogenetic Testing In a Mental Health Population and Economic Outcomes https://ClinicalTrials.gov/show/NCT02474680 Completed Avera McKennan Hospital & University Health Center 2017-01-01
NCT02429011 MRI Studies of Emotion in Depression https://ClinicalTrials.gov/show/NCT02429011 Completed Icahn School of Medicine at Mount Sinai 2016-05-31
NCT02330068 Microbiome of Depression & Treatment Response to Citalopram https://ClinicalTrials.gov/show/NCT02330068 Completed Mayo Clinic 2017-12-31
NCT02307617 Glutamate Probes in Adolescent Depression https://ClinicalTrials.gov/show/NCT02307617 Active, not recruiting Mayo Clinic 2018-12-31
NCT02286024 Study of Morphological and Perfusion Imaging Predictors of Pejorative Outcome in Major Depressive Disorder https://ClinicalTrials.gov/show/NCT02286024 Active, not recruiting Rennes University Hospital 2018-09-30
NCT02230592 PET Imaging of Brain mGluR1 Receptors Using [18F]FIMX https://ClinicalTrials.gov/show/NCT02230592 Completed National Institutes of Health Clinical Center (CC) 2016-06-16
NCT02180607 Neuronal Responses to Social Feedback in Major Depressive Disorder https://ClinicalTrials.gov/show/NCT02180607 Completed University of Michigan 2014-10-31
NCT01284218 Retrospective Database Study of Real World Abilify Outcomes in Major Depressive Disorder (MDD) https://ClinicalTrials.gov/show/NCT01284218 Completed Otsuka Pharmaceutical Development & Commercialization, Inc. 2011-12-31
NCT01269710 Second-Generation Antipsychotic Treatment Indication Effectiveness And Tolerability In Youth (Satiety) Study https://ClinicalTrials.gov/show/NCT01269710 Completed University of North Carolina, Chapel Hill 2011-03-31
NCT02039960 PRJ2215: Assessment of Buproprion Misuse/Abuse 2004-2011 https://ClinicalTrials.gov/show/NCT02039960 Completed GlaxoSmithKline 2014-01-31
NCT01976975 Brain Mechanisms of Human Motivation https://ClinicalTrials.gov/show/NCT01976975 Completed Mclean Hospital 2018-01-31
NCT01851356 Brain Inflammation in Major Depressive Disorder Background https://ClinicalTrials.gov/show/NCT01851356 Completed National Institutes of Health Clinical Center (CC) 2017-07-27
NCT01831882 Identifying Biological Markers for Severe Depression https://ClinicalTrials.gov/show/NCT01831882 Recruiting Stanford University 2020-08-31
NCT01795326 Physician Survey on Monitoring of Patients Treated With Quetiapine https://ClinicalTrials.gov/show/NCT01795326 Completed AstraZeneca 2013-09-30
NCT01793324 EMR Data to Assess Monitoring of Patients Treated With Quetiapine https://ClinicalTrials.gov/show/NCT01793324 Completed AstraZeneca 2013-06-30
NCT01743716 Genetic and Neural Predictors of Adolescent Depression https://ClinicalTrials.gov/show/NCT01743716 Active, not recruiting Mclean Hospital 2020-12-31
NCT01731899 Agomelatine in Depressed Patients With Fibromyalgia https://ClinicalTrials.gov/show/NCT01731899 Completed Universidad de Granada 2012-10-31
NCT01718730 Cortical Excitability and Inhibition in MDD https://ClinicalTrials.gov/show/NCT01718730 Completed Mayo Clinic 2019-08-31
NCT01719315 Neurophysiologic Correlates of Hypersomnia https://ClinicalTrials.gov/show/NCT01719315 Completed University of Wisconsin, Madison 2018-06-30
NCT01710202 Sensitivity of Short and Long Allele Carriers of the 5-HTTLPR to Environmental Threat Post Hydrocortisone Administration https://ClinicalTrials.gov/show/NCT01710202 Completed University of Texas at Austin 2013-12-31
NCT01701141 Depression and Dopamine Transporter Function Study Using C-11 Altropane https://ClinicalTrials.gov/show/NCT01701141 Completed Mclean Hospital 2014-07-31
NCT01659814 Dopamine Neurotransmission in Major Depression https://ClinicalTrials.gov/show/NCT01659814 Completed Mclean Hospital 2012-12-31
NCT01594996 European Drug Utilization Study https://ClinicalTrials.gov/show/NCT01594996 Completed AstraZeneca 2014-03-27
NCT01583569 Complex Dynamic Systems in Mood Disorders https://ClinicalTrials.gov/show/NCT01583569 Completed Massachusetts General Hospital 2014-06-30
NCT01575912 Past Pain Experience and Perception of Experimental Pain https://ClinicalTrials.gov/show/NCT01575912 Completed Centre Hospitalier Esquirol 2014-01-31
NCT01569711 Deep Brain Stimulation of Nucleus Accumbens for Chronic and Resistant Major Depressive Disorder https://ClinicalTrials.gov/show/NCT01569711 Completed Rennes University Hospital 2013-05-31
NCT01528748 Clinical Trial of CBASP for Individuals With Co-occurring Chronic Depression and Alcohol Dependence https://ClinicalTrials.gov/show/NCT01528748 Completed University of Virginia 2015-12-31
NCT01506206 ON/OFF Stimulation and Impulsivity in Patients With Deep Brain Stimulators https://ClinicalTrials.gov/show/NCT01506206 Recruiting Massachusetts General Hospital 2020-12-31
NCT01447082 General Practice Research Database Seroquel XR Safety Study https://ClinicalTrials.gov/show/NCT01447082 Completed AstraZeneca 2012-12-31
NCT01446692 Badalona Major Depressive Disorder Database Study https://ClinicalTrials.gov/show/NCT01446692 Completed AstraZeneca NA
NCT01430767 Measuring Adherence to Medication for Depression and Attention-deficit Hyperactivity Disorder https://ClinicalTrials.gov/show/NCT01430767 Completed Wake Forest University Health Sciences 2014-12-31
NCT01427439 A Prospective Epidemiological Research on Functioning Outcomes Related to Major Depressive Disorder https://ClinicalTrials.gov/show/NCT01427439 Completed H. Lundbeck A/S 2015-02-28
NCT01426997 Phenotype Depression Study https://ClinicalTrials.gov/show/NCT01426997 Completed Emory University 2016-05-31
NCT01424111 Exploring Biomarkers for Depression https://ClinicalTrials.gov/show/NCT01424111 Completed Wyss Institute at Harvard University 2017-10-14
NCT01397903 Description of Treatment Management of Patients With Major Depressive Disorder and Inadequate Response https://ClinicalTrials.gov/show/NCT01397903 Completed AstraZeneca 2012-03-31
NCT01385709 The Influence of the Menstrual Cycle on Lithium and Sertraline Blood Levels https://ClinicalTrials.gov/show/NCT01385709 Completed Weill Medical College of Cornell University 2012-08-31
NCT01377896 The Purpose of the Study is to Gain an In-depth Picture of the Patient Management and Prescription Behaviours https://ClinicalTrials.gov/show/NCT01377896 Completed AstraZeneca 2010-10-31
NCT01369030 Deplin® P.L.U.S. Program (Progress Through Learning Understanding & Support) https://ClinicalTrials.gov/show/NCT01369030 Completed Pamlab, Inc. 2012-04-30
NCT01357083 The Study of Serum Melatonin Rhythm Levels in Patients With Major Depressive Disorder https://ClinicalTrials.gov/show/NCT01357083 Completed Science & Research Islamic Azad University Branch Khozestan 2010-10-31
NCT01344733 A Non Interventional Study to Investigating the Ratio of Mis-diagnosed Bipolar Symptoms in Patient With Major Depressive Disorder (MDD) https://ClinicalTrials.gov/show/NCT01344733 Completed AstraZeneca 2012-03-31
NCT01342380 Pioglitazone and Quetiapine XR Pharmacogenetic Study https://ClinicalTrials.gov/show/NCT01342380 Completed University Hospitals Cleveland Medical Center 2015-05-31
NCT01342120 PHARMO Institute Seroquel Safety Study https://ClinicalTrials.gov/show/NCT01342120 Completed AstraZeneca 2010-11-30
NCT04347577 Intestinal Flora and Major Depressive Disorders https://ClinicalTrials.gov/show/NCT04347577 Recruiting Beijing Chao Yang Hospital 2022-10-01
NCT04342299 The Antidepressant Advisor (Study 3): fMRI Study to Predict Treatment Response in Patients With Depression https://ClinicalTrials.gov/show/NCT04342299 Recruiting King’s College London 2021-04-30
NCT04253678 Vortioxetine for Cancer Patients With Depression: An Observational Study https://ClinicalTrials.gov/show/NCT04253678 Recruiting University of Malaya 2020-07-31
NCT04208932 A Kynurenine Pathway-based Molecular Imaging Study of Individualized Diagnosis and Treatment for Major Depressive Disorder https://ClinicalTrials.gov/show/NCT04208932 Recruiting Shanghai Mental Health Center 2021-12-31
NCT04195659 Chest Dysphoria in Transmasculine Spectrum Adolescents https://ClinicalTrials.gov/show/NCT04195659 Enrolling by invitation Northwestern University 2020-11-01
NCT04159207 A Longitudinal Study of Inflammatory Pathways in Depression https://ClinicalTrials.gov/show/NCT04159207 Recruiting Van Andel Research Institute 2024-06-30
NCT04158869 An Investigation of the Relationship Between Omega-3 Fatty Acid Nutrition and Mental Health in Children and Adolescents https://ClinicalTrials.gov/show/NCT04158869 Recruiting Swiss Federal Institute of Technology 2020-12-31
NCT04114565 Prevalence of Mood Disorders and Mental Health Service Use Among Immigrants in Santiago, Chile https://ClinicalTrials.gov/show/NCT04114565 Recruiting Pontificia Universidad Catolica de Chile 2019-11-30
NCT04104698 Cognitive, Psychological and Electrophysiological Attributes to Suicide Among Depressed Patients https://ClinicalTrials.gov/show/NCT04104698 Recruiting Mansoura University 2020-07-15
NCT04006834 Hypersomnia in Major Depressive Disorder https://ClinicalTrials.gov/show/NCT04006834 Recruiting Chinese University of Hong Kong 2020-02-28
NCT04000022 Repetitive Transcranial Magnetic Stimulation in Pharmaco-naïve Patients With Major Depression https://ClinicalTrials.gov/show/NCT04000022 Recruiting University Hospital, Bonn 2020-12-29
NCT03953014 Pharmacogenetics of Antidepressant-Induced Disinhibition https://ClinicalTrials.gov/show/NCT03953014 Recruiting University of Calgary 2022-08-31
NCT03898297 Imaging mGluR5 and Synaptic Density in Psychiatric Disorders https://ClinicalTrials.gov/show/NCT03898297 Recruiting Yale University 2022-01-31
NCT03774641 A Pilot Study of Prophylactic Management of Lamotrigine in Pregnant Women https://ClinicalTrials.gov/show/NCT03774641 Recruiting Johns Hopkins University 2020-12-31
NCT03721588 Clinical and Suicidal Features of Urban, Turkish Middle Age Depressive Patients With Comorbid ADHD https://ClinicalTrials.gov/show/NCT03721588 Completed Bozyaka Training and Research Hospital 2017-06-01
NCT03711045 An Eye Tracking Study of Affective Disorder Patients With Suicide Risk https://ClinicalTrials.gov/show/NCT03711045 Recruiting Central South University 2019-12-31
NCT03670823 Prediction of SSRI Treatment in Major Depression. https://ClinicalTrials.gov/show/NCT03670823 Recruiting ElMindA Ltd 2020-10-01
NCT03615794 A Study of Pregnant and Postpartum Women With and Without Mood Disorders https://ClinicalTrials.gov/show/NCT03615794 Recruiting Johns Hopkins University 2021-10-31
NCT03555136 Real-life Effectiveness of Vortioxetine in Depression https://ClinicalTrials.gov/show/NCT03555136 Recruiting H. Lundbeck A/S 2020-06-30
NCT03429361 Testing the Value of Smartphone Assessments of People With Mood Disorders https://ClinicalTrials.gov/show/NCT03429361 Completed Mindstrong 2019-05-30
NCT03432221 Switching From SSRI to Desvenlafaxine on Cognitive Functioning https://ClinicalTrials.gov/show/NCT03432221 Recruiting Corporacion Parc Tauli 2019-06-03
NCT01221935 Retrospective Study Evaluating The Current Utilization Of Desvenlafaxine Succinate Sustained-Release (Pristiq) Among Psychiatrists And Primary Care Physicians In The Treatment Of Patients With Major Depressive Disorder https://ClinicalTrials.gov/show/NCT01221935 Completed Pfizer 2010-01-31
NCT01182103 Epigenetic Regulation of BDNF in Major Depression https://ClinicalTrials.gov/show/NCT01182103 Completed Chang Gung Memorial Hospital 2012-07-31
NCT01145313 Impact of Atypical Antipsychotic Therapy on Health Outcomes and Costs Among Patients With Major Depressive Disorder https://ClinicalTrials.gov/show/NCT01145313 Completed Otsuka Pharmaceutical Development & Commercialization, Inc. 2010-06-30
NCT01141400 The Effect of Patient Cost-Sharing on Antidepressant and Adjunctive Therapy Use https://ClinicalTrials.gov/show/NCT01141400 Completed Otsuka Pharmaceutical Development & Commercialization, Inc. 2010-10-31
NCT01141387 Outcomes in MEasurement-Based Treatment https://ClinicalTrials.gov/show/NCT01141387 Completed Otsuka Pharmaceutical Development & Commercialization, Inc. 2010-08-31
NCT01129752 Mothers With a History of Depression and Their 10-14 Year Old Daughters https://ClinicalTrials.gov/show/NCT01129752 Completed Stanford University 2011-04-30
NCT01114477 NeuroStar TMS Therapy System: Utilization and Outcomes https://ClinicalTrials.gov/show/NCT01114477 Completed Neuronetics 2012-09-30
NCT01106313 Insulin Resistance in Patients With Major Depression https://ClinicalTrials.gov/show/NCT01106313 Completed Stanford University 2016-01-31
NCT01101373 Treatment of Severe Depressive Illness by Targeted Brain Surgery https://ClinicalTrials.gov/show/NCT01101373 Completed University of British Columbia 2009-11-30
NCT01001559 Combination Deplin® and Antidepressant Therapy for a Major Depressive Episode (MDE)- a Retrospective Analysis https://ClinicalTrials.gov/show/NCT01001559 Completed Pamlab, Inc. 2010-12-31
NCT00931619 GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression https://ClinicalTrials.gov/show/NCT00931619 Completed National Institutes of Health Clinical Center (CC) NA
NCT03944213 Resting-state Functional Connectivity Throughout a Course of iTBS in Major Depression https://ClinicalTrials.gov/show/NCT03944213 Recruiting University Hospital, Bonn 2020-02-01
NCT01662817 Major Depressive Disorder (MDD) https://ClinicalTrials.gov/show/NCT01662817 Completed Eli Lilly and Company 2010-07-31
NCT01590862 ON/OFF Stimulation and Reward Motivation in Patients With Deep Brain Stimulators https://ClinicalTrials.gov/show/NCT01590862 Recruiting Massachusetts General Hospital 2020-12-31
NCT02740296 Depression and Immune Function in Multiple Sclerosis (MS) https://ClinicalTrials.gov/show/NCT02740296 Completed Charite University, Berlin, Germany 2017-06-30
NCT02409823 Clinical Registry of Patients Under Treatment With Atypical Antipsychotics https://ClinicalTrials.gov/show/NCT02409823 Completed Pontifical Catholic University of Argentina 2015-08-31
NCT04353921 A Two-Year Observational Follow-up Study of Subjects With Major Depressive Disorder Following a Randomized, Double-Blind Single-Dose of Psilocybin or Niacin-Control https://ClinicalTrials.gov/show/NCT04353921 Enrolling by invitation Usona Institute 2022-10-31
NCT00784199 Validating PROMIS Instruments in Depression https://ClinicalTrials.gov/show/NCT00784199 Completed University of Pittsburgh 2010-07-31
NCT00782964 Antidepressant Incomplete Response Depression https://ClinicalTrials.gov/show/NCT00782964 Completed AstraZeneca NA
NCT00781677 Using Neuroimaging to Investigate Major Depressive Disorder https://ClinicalTrials.gov/show/NCT00781677 Completed University of Texas Southwestern Medical Center 2009-10-20
NCT00770289 Study Comparing Remission Rates, in Patients With Major Depressive Disorder (MDD) https://ClinicalTrials.gov/show/NCT00770289 Completed Pfizer 2009-12-31
NCT00705185 Exploring a Potential Blood Test to Diagnose Major Depressive Disorder https://ClinicalTrials.gov/show/NCT00705185 Completed Massachusetts General Hospital 2010-06-30
NCT00697268 p11 Protein Levels in Patients With Major Depressive Disorder Treated With Citalopram https://ClinicalTrials.gov/show/NCT00697268 Completed National Institutes of Health Clinical Center (CC) NA
NCT00691535 Genetics of Symptomatology and Treatment Response in Psychotic Major Depression https://ClinicalTrials.gov/show/NCT00691535 Completed Stanford University 2012-06-30
NCT00616889 Effect of Quetiapine on Sleep Architecture in Bipolar Depression and Major Depressive Disorder https://ClinicalTrials.gov/show/NCT00616889 Completed Queen’s University 2009-01-31
NCT00613912 Advanced MRI in Major Depression https://ClinicalTrials.gov/show/NCT00613912 Completed University of Aarhus 2009-12-31
NCT00576095 Clinical and Biological Characteristics of Psychotic Depression https://ClinicalTrials.gov/show/NCT00576095 Completed Stanford University 2012-06-30
NCT00561509 Multi-Country Observational Study to Collect the Frequency of Sexual Dysfunction With Antidepressant Treatment, Either With SSRIs or Duals at 8 Weeks and 6 Months https://ClinicalTrials.gov/show/NCT00561509 Completed Eli Lilly and Company NA
NCT00369746 STAR*D Alcohol: Treatment of Depression Concurrent With Alcohol Abuse https://ClinicalTrials.gov/show/NCT00369746 Completed New York State Psychiatric Institute 2009-02-28
NCT00360256 Genetic Study of Liver Enzymes in Patients With Side Effects From Antidepressants https://ClinicalTrials.gov/show/NCT00360256 Completed Augusta University 2007-12-31
NCT00320372 Treatment-Resistant Depression Registry https://ClinicalTrials.gov/show/NCT00320372 Completed Cyberonics, Inc. 2015-03-31
NCT00289523 EEG Biomarkers for Predicting Response to Antidepressant Therapy https://ClinicalTrials.gov/show/NCT00289523 Completed Medtronic - MITG 2007-07-31
NCT00286546 Testosterone and Major Depression https://ClinicalTrials.gov/show/NCT00286546 Completed University Health Network, Toronto NA
NCT00260468 Brain Abnormalities in Late-Onset Major Depression https://ClinicalTrials.gov/show/NCT00260468 Completed University of Aarhus NA
NCT00229463 Study of Genetic Differences in People With Depression https://ClinicalTrials.gov/show/NCT00229463 Completed University of California, Los Angeles 2011-01-31
NCT00223288 Impact of Caregiver Depression on Asthma in the Child https://ClinicalTrials.gov/show/NCT00223288 Completed University of Texas Southwestern Medical Center 2006-02-28
NCT00229398 Medical and Psychiatric Co-Morbidity Among Treatment Resistant Patients With Major Depression Disorder https://ClinicalTrials.gov/show/NCT00229398 Completed Sheba Medical Center 2004-12-31
NCT00229294 Fibromyalgia in Men Suffering From PTSD https://ClinicalTrials.gov/show/NCT00229294 Completed Sheba Medical Center NA
NCT00209105 Characterizing Psychological Consequences of Childhood Trauma https://ClinicalTrials.gov/show/NCT00209105 Completed Emory University 2009-12-31
NCT00209066 Treatment of Reduced Heart Rate Variability Associated With Major Depression With Electroconvulsive Therapy https://ClinicalTrials.gov/show/NCT00209066 Completed Emory University NA
NCT00205933 Behavioral Processes Underlying Reward Processing in Depression https://ClinicalTrials.gov/show/NCT00205933 Completed Affective Neuroscience Laboratory NA
NCT00116077 Dopamine Receptor Imaging in Mood Disorders https://ClinicalTrials.gov/show/NCT00116077 Completed National Institutes of Health Clinical Center (CC) NA
NCT00097175 Effects of Tryptophan Depletion on Brain Processing of Emotions in Patients With Mood Disorders https://ClinicalTrials.gov/show/NCT00097175 Completed National Institutes of Health Clinical Center (CC) NA
NCT00084162 Neurocardiac Control in Major Depression https://ClinicalTrials.gov/show/NCT00084162 Completed National Institutes of Health Clinical Center (CC) NA
NCT00075296 FMRI Study of Performance During a Probabilistic Reversal Learning Task in Depression https://ClinicalTrials.gov/show/NCT00075296 Completed National Institutes of Health Clinical Center (CC) NA
NCT00071123 Evaluating Brain Responses to Facial Expressions in Major Depressive Disorder https://ClinicalTrials.gov/show/NCT00071123 Completed National Institutes of Health Clinical Center (CC) NA
NCT00059579 Brain Regulation of Emotions in People With Depression and Anhedonia https://ClinicalTrials.gov/show/NCT00059579 Completed National Institutes of Health Clinical Center (CC) NA
NCT00001916 Use of Bone Biopsy to Better Understand the Causes of Decreased Bone Mineral Density in Depression https://ClinicalTrials.gov/show/NCT00001916 Completed National Institutes of Health Clinical Center (CC) NA
NCT00818506 Associations Between Depression and Cardiovascular Disease - a Study of Patients With Late Onset Depression https://ClinicalTrials.gov/show/NCT00818506 Completed University of Aarhus NA
NCT00047944 MRI Study of Brain Activity and Risk for Depression in Adolescents https://ClinicalTrials.gov/show/NCT00047944 Completed National Institutes of Health Clinical Center (CC) NA
NCT00033787 Serotonin Function During Depression https://ClinicalTrials.gov/show/NCT00033787 Completed National Institutes of Health Clinical Center (CC) 2005-04-30
NCT00025974 Brain Chemical Receptor Effects in Patients With Panic Disorder and Post-Traumatic Stress Disorder https://ClinicalTrials.gov/show/NCT00025974 Completed National Institutes of Health Clinical Center (CC) NA
NCT00025857 Brain Function in Mentally Ill Adolescents https://ClinicalTrials.gov/show/NCT00025857 Completed National Institutes of Health Clinical Center (CC) NA
NCT00001543 Dynamics of Leptin and Endocrine Function https://ClinicalTrials.gov/show/NCT00001543 Completed National Institutes of Health Clinical Center (CC) NA
NCT00001413 Bone Mineral Density in Women With Major Depression https://ClinicalTrials.gov/show/NCT00001413 Completed National Institutes of Health Clinical Center (CC) NA
NCT00001969 Heart Disease Risk Factors in Major Depression https://ClinicalTrials.gov/show/NCT00001969 Completed National Institutes of Health Clinical Center (CC) NA
NCT00001170 Study of the Psychological Development of Children of Parents With and Without Affective Disorders https://ClinicalTrials.gov/show/NCT00001170 Completed National Institutes of Health Clinical Center (CC) NA

Registries

#If less then 500 registries

nct_id brief_title link overall_status source primary_completion_date
NCT03088657 Design and Methods of the Mood Disorder Cohort Research Consortium (MDCRC) Study https://ClinicalTrials.gov/show/NCT03088657 Recruiting Korea University Anam Hospital 2022-07-31
NCT02871141 Multimodal Imaging of ECT Effects https://ClinicalTrials.gov/show/NCT02871141 Recruiting Charite University, Berlin, Germany 2020-08-31
NCT02453438 Mood Patient Powered Research Network (MoodNetwork) https://ClinicalTrials.gov/show/NCT02453438 Completed Massachusetts General Hospital 2019-03-31
NCT02156622 CID 0911 - Adaptation of A Depression Treatment Intervention for HIV Patients in Cameroon https://ClinicalTrials.gov/show/NCT02156622 Completed University of North Carolina, Chapel Hill 2012-11-30
NCT02099630 Functional and Metabolic Changes in the Course of Antidepressive Treatment https://ClinicalTrials.gov/show/NCT02099630 Completed Charite University, Berlin, Germany 2019-11-30
NCT01887639 Prevalence and Risk Factors in Unipolar Depression Patients Without Remission After One Antidepressant Trial https://ClinicalTrials.gov/show/NCT01887639 Completed AstraZeneca 2014-09-30
NCT04226963 A Naturalistic Study of Ketamine for Treatment Resistant Mood Disorders https://ClinicalTrials.gov/show/NCT04226963 Recruiting Medical University of Gdansk 2022-12-31
NCT03977038 Investigation of the Effects of Repetitive Transcranial Magnetic Stimulation on Cognition in Depression https://ClinicalTrials.gov/show/NCT03977038 Recruiting Sunnybrook Health Sciences Centre 2020-04-30
NCT03795688 The Role of Sex Steroids and Serotonin Brain Dynamics in Perinatal Mental Health https://ClinicalTrials.gov/show/NCT03795688 Recruiting Rigshospitalet, Denmark 2024-01-01
NCT00762866 Psychiatric Genotype/Phenotype Project Repository https://ClinicalTrials.gov/show/NCT00762866 Enrolling by invitation Vanderbilt University Medical Center 2020-12-31